Research workbench
Crystal structure of the catalytic alpha subunit of E. COLI replicative DNA polymerase III
Analyse Crystal structure of the catalytic alpha subunit of E. COLI replicative DNA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HNH
- Type
- protein
- Length
- 910 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA polymerase III alpha subunit
- EC
- 2.7.7.7
- UniProt
- P10443
- Ligands
- PO4
- Pockets
- 6 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 52% helix, 9% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA polymerase III alpha subunit (EC 2.7.7.7) | protein | 910 | 52% helix, 9% strand | P10443 |
Ligands and binding sites
- PO4 · Phosphate ion · ion · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 408 | 0.71 | 0.82 | 54 | empty |
| 2 | 528 | 0.66 | 0.77 | 75 | PO4 |
| 3 | 61 | 0.42 | 0.81 | 12 | empty |
| 4 | 144 | 0.40 | 0.74 | 22 | empty |
| 5 | 89 | 0.36 | 0.75 | 17 | empty |
Compared structures
- 2HNH · Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III · the same entry in another collection · chain A against A, TM-score 1.00
- P10443 · AlphaFold monomer V2.0 prediction for DNA polymerase III subunit alpha (P10443) · a predicted model of the same protein · chain A against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10443
- Elsewhere: RCSB PDB 2HNH · PDBe 2HNH · UniProt P10443
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