Research workbench
Structure of an anti-prp Fab, P-clone, in complex with its cognate bovine peptide epitope.
Analyse Structure of an anti-prp Fab, P-clone, in complex with its cognate bovine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HH0
- Type
- protein
- Length
- 436 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Light chain, P-clone Fab, chimera; Heavy chain, P-clone Fab, chimera; Prion protein
- UniProt
- Q5UK71
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 3 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Light chain, P-clone Fab, chimera | protein | 210 | 6% helix, 51% strand | — |
| H | Heavy chain, P-clone Fab, chimera | protein | 217 | 8% helix, 52% strand | — |
| P | Prion protein | protein | 9 | 0% helix, 0% strand | Q5UK71 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 759 | 0.66 | 0.74 | 56 | empty |
| 2 | 52 | 0.26 | 0.73 | 12 | empty |
Interfaces
3 interfaces between chains.
- L–H · 1735 Ų buried · 14 hydrogen bonds · protein-protein
- H–P · 535 Ų buried · 8 hydrogen bonds · protein-protein
- L–P · 292 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 2HH0 · Structure of an Anti-PrP Fab, P-Clone, in Complex with its Cognate Bovine Peptide Epitope. · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5UK71
- Elsewhere: RCSB PDB 2HH0 · PDBe 2HH0 · UniProt Q5UK71
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