Research workbench
Transcription factor iiia zinc fingers 4-6 bound to 5S rRNA 55MER (NMR structure)
Analyse Transcription factor iiia zinc fingers 4-6 bound to 5S rRNA 55MER (NMR… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HGH
- Type
- protein + RNA
- Length
- 142 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 55-mer; Transcription factor iiia
- UniProt
- P03001
- Ligands
- ZN
- Pockets
- 4 · best druggability 0.67
Structure
solution nmr · 2 distinct chains · 40% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | 55-mer | rna | 55 | — | — |
| A | Transcription factor iiia | protein | 87 | 40% helix, 14% strand | P03001 |
Ligands and binding sites
- ZN · Zinc ion · metal · 3 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 618 | 0.67 | 0.78 | 34 | empty |
| 2 | 85 | 0.33 | 0.75 | 15 | empty |
| 3 | 77 | 0.32 | 0.75 | 13 | empty |
| 4 | 54 | 0.28 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- B–A · 1191 Ų buried · 46 hydrogen bonds · protein-nucleic
Compared structures
- 2HGH · Transcription Factor IIIA zinc fingers 4-6 bound to 5S rRNA 55mer (NMR structure) · the same entry in another collection · chain B against B, TM-score 1.00
- P03001 · AlphaFold monomer V2.0 prediction for transcription factor iiia (P03001) · a predicted model of the same protein · chain A against A, TM-score 0.67
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03001
- Elsewhere: RCSB PDB 2HGH · PDBe 2HGH · UniProt P03001
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