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Crystal structure of E. COLI DNA topoisomerase III

Analyse Crystal structure of E. COLI DNA topoisomerase III in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1D6M
Type: protein
Length: 603 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: DNA topoisomerase III
EC: 5.99.1.2
UniProt: P14294
Pockets: 4 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 45% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	DNA topoisomerase III (EC 5.99.1.2)	protein	603	45% helix, 18% strand	P14294

Pockets

4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	639	0.66	0.76	70	empty
2	530	0.65	0.76	55	empty
3	341	0.64	0.80	35	empty
4	67	0.33	0.76	18	empty

Compared structures

1D6M · Crystal structure of E. COLI DNA topoisomerase III · the same entry in another collection · chain A against A, TM-score 1.00
P14294 · AlphaFold monomer V2.0 prediction for DNA topoisomerase 3 (P14294) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P14294
Elsewhere: RCSB PDB 1D6M · PDBe 1D6M · UniProt P14294

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