Research workbench
Crystal structure of the complex between OX40L and OX40
Analyse Crystal structure of the complex between OX40L and OX40 in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HEV
- Type
- protein
- Length
- 266 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor necrosis factor ligand superfamily member 4; Tumor necrosis factor receptor…
- UniProt
- P23510, P43489
- Ligands
- NAG
- Pockets
- 1 · best druggability 0.52
Structure
x-ray diffraction · 2 distinct chains · 1% helix, 48% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| F | Tumor necrosis factor ligand superfamily member 4 | protein | 126 | 0% helix, 61% strand | P23510 |
| R | Tumor necrosis factor receptor superfamily member 4 | protein | 140 | 2% helix, 36% strand | P43489 |
Ligands and binding sites
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 2 copies · chains F, R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 284 | 0.52 | 0.75 | 48 | empty |
Interfaces
1 interface between chains.
- F–R · 490 Ų buried · 11 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide, 2 glycan (disulfide, N-glycosylation).
Compared structures
- 2HEV · Crystal structure of the complex between OX40L and OX40 · the same entry in another collection · chain F against F, TM-score 1.00
- P23510 · AlphaFold monomer V2.0 prediction for tumor necrosis factor ligand superfamily member 4… · a predicted model of the same protein · chain F against A, TM-score 0.98
- P43489 · AlphaFold monomer V2.0 prediction for tumor necrosis factor receptor superfamily member 4… · a predicted model of the same protein · chain R against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P23510
- Every structure of UniProt P43489
- Elsewhere: RCSB PDB 2HEV · PDBe 2HEV · UniProt P23510 · UniProt P43489
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.