Research workbench

Crystal structure of the KIF2C motor domain

Analyse Crystal structure of the KIF2C motor domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2HEH
Type: protein
Length: 324 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: KIF2C protein
UniProt: Q99661
Ligands: ADP, MG, UNX
Pockets: 1 · best druggability 0.47

Structure

x-ray diffraction · 1 distinct chain · 37% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	KIF2C protein	protein	324	37% helix, 29% strand	Q99661

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
MG · Magnesium ion · metal · chains A
UNX · Unknown atom or ion · ion · 10 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	124	0.47	0.78	21	UNX

Compared structures

2HEH · Crystal Structure of the KIF2C motor domain · the same entry in another collection · chain A against A, TM-score 1.00
Q99661 · AlphaFold monomer V2.0 prediction for kinesin-like protein KIF2C (Q99661) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99661
Elsewhere: RCSB PDB 2HEH · PDBe 2HEH · UniProt Q99661

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.