Research workbench
Crystal structure of the ethanolamine utilization protein eutn from escherichia COLI, nesg target ER316
Analyse Crystal structure of the ethanolamine utilization protein eutn from escherichia… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2HD3
- Type
- protein
- Length
- 1,110 residues
- Chains
- 12
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ethanolamine utilization protein eutn
- UniProt
- P0AEJ9
- Pockets
- 14 · best druggability 0.62
Structure
x-ray diffraction · 8 distinct chains · 6% helix, 52% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D, G | Ethanolamine utilization protein eutn | protein | 96 | 10% helix, 48% strand | P0AEJ9 |
| B, E, H | Ethanolamine utilization protein eutn | protein | 97 | 7% helix, 51% strand | P0AEJ9 |
| C | Ethanolamine utilization protein eutn | protein | 84 | 4% helix, 58% strand | P0AEJ9 |
| F | Ethanolamine utilization protein eutn | protein | 79 | 0% helix, 57% strand | P0AEJ9 |
| I | Ethanolamine utilization protein eutn | protein | 88 | 5% helix, 53% strand | P0AEJ9 |
| J | Ethanolamine utilization protein eutn | protein | 91 | 7% helix, 53% strand | P0AEJ9 |
| K | Ethanolamine utilization protein eutn | protein | 95 | 8% helix, 52% strand | P0AEJ9 |
| L | Ethanolamine utilization protein eutn | protein | 94 | 9% helix, 50% strand | P0AEJ9 |
Pockets
14 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 172 | 0.62 | 0.84 | 25 | empty |
| 2 | 418 | 0.62 | 0.77 | 50 | empty |
| 3 | 91 | 0.53 | 0.84 | 20 | empty |
| 4 | 258 | 0.51 | 0.74 | 51 | empty |
| 5 | 141 | 0.46 | 0.77 | 23 | empty |
Interfaces
15 interfaces between chains.
- H–I · 1026 Ų buried · 20 hydrogen bonds · protein-protein
- G–H · 1012 Ų buried · 21 hydrogen bonds · protein-protein
- D–E · 993 Ų buried · 19 hydrogen bonds · protein-protein
- A–B · 983 Ų buried · 19 hydrogen bonds · protein-protein
- J–K · 972 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 36 modified (engineered).
Compared structures
- 2HD3 · Crystal Structure of the Ethanolamine Utilization Protein EutN from Escherichia coli… · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AEJ9
- Elsewhere: RCSB PDB 2HD3 · PDBe 2HD3 · UniProt P0AEJ9
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