Research workbench
Human sulfotranferase SULT1C3 in complex with pap
Analyse Human sulfotranferase SULT1C3 in complex with pap in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H8K
- Type
- protein
- Length
- 490 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- SULT1C3 splice variant D
- EC
- 2.8.2.-
- UniProt
- Q6IMI6
- Ligands
- A3P
- Pockets
- 6 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | SULT1C3 splice variant D (EC 2.8.2.-) | protein | 245 | 45% helix, 13% strand | Q6IMI6 |
Ligands and binding sites
- A3P · Adenosine-3'-5'-diphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 490 | 0.80 | 0.86 | 61 | A3P |
| 2 | 480 | 0.79 | 0.86 | 58 | A3P |
| 3 | 134 | 0.66 | 0.88 | 25 | empty |
| 4 | 114 | 0.66 | 0.89 | 22 | empty |
| 5 | 98 | 0.53 | 0.83 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 325 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q6IMI6
- Elsewhere: RCSB PDB 2H8K · PDBe 2H8K · UniProt Q6IMI6
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