Research workbench

Protein kinase domain of the human 5'-AMP-activated protein kinase catalytic subunit alpha-2 (ampk alpha-2 chain)

Analyse Protein kinase domain of the human 5'-AMP-activated protein kinase catalytic… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2H6D
Type: protein
Length: 256 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 5'-AMP-activated protein kinase catalytic subunit alpha-2
EC: 2.7.11.1
UniProt: P54646
Pockets: 2 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	5'-AMP-activated protein kinase catalytic subunit alpha-2 (EC 2.7.11.1)	protein	256	43% helix, 19% strand	P54646

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	336	0.80	0.90	44	empty
2	100	0.39	0.75	21	empty

Compared structures

2H6D · Protein Kinase Domain of the Human 5'-AMP-activated protein kinase catalytic subunit… · the same entry in another collection · chain A against A, TM-score 1.00
P54646 · AlphaFold monomer V2.0 prediction for 5'-AMP-activated protein kinase catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P54646
Elsewhere: RCSB PDB 2H6D · PDBe 2H6D · UniProt P54646

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.