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Crystal structure of laccase from cerrena maxima at 1.9A resolution

Analyse Crystal structure of laccase from cerrena maxima at 1.9A resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2H5U
Type: protein
Length: 499 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Laccase
EC: 1.10.3.2
Ligands: NAG, MAN, CU
Pockets: 5 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 11% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Laccase (EC 1.10.3.2)	protein	499	11% helix, 38% strand	—

Ligands and binding sites

NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 6 copies · chains A
MAN · alpha-D-mannopyranose · sugar · 4 copies · chains A
CU · Copper (II) ion · metal · 4 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	121	0.54	0.82	22	empty
2	117	0.42	0.76	16	empty
3	85	0.42	0.79	18	empty
4	111	0.37	0.74	17	empty
5	57	0.30	0.75	16	empty

Modifications

Observed in the structure: 4 glycan, 2 disulfide, 2 modified (N-glycosylation, disulfide, nonstandard).

Compared structures

2H5U · Crystal structure of laccase from Cerrena maxima at 1.9A resolution · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2H5U · PDBe 2H5U

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