Research workbench
Crystal structure of ORF52 from murid herpesvirus 4 (muhv-4) (murine gammaherpesvirus 68). northeast structural genomics consortium target MHR28B.
Analyse Crystal structure of ORF52 from murid herpesvirus 4 (muhv-4) (murine… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H3R
- Type
- protein
- Length
- 355 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical protein BQLF2
- UniProt
- P88989
- Pockets
- 3 · best druggability 0.55
Structure
x-ray diffraction · 4 distinct chains · 71% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical protein BQLF2 | protein | 90 | 71% helix, 10% strand | P88989 |
| B | Hypothetical protein BQLF2 | protein | 88 | 72% helix, 10% strand | P88989 |
| C | Hypothetical protein BQLF2 | protein | 89 | 72% helix, 10% strand | P88989 |
| D | Hypothetical protein BQLF2 | protein | 88 | 70% helix, 10% strand | P88989 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 104 | 0.55 | 0.84 | 24 | empty |
| 2 | 88 | 0.51 | 0.83 | 23 | empty |
| 3 | 64 | 0.29 | 0.73 | 12 | empty |
Interfaces
4 interfaces between chains.
- C–D · 2124 Ų buried · 41 hydrogen bonds · protein-protein
- A–B · 2113 Ų buried · 25 hydrogen bonds · protein-protein
- B–D · 215 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 169 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 2H3R · Crystal structure of ORF52 from Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P88989
- Elsewhere: RCSB PDB 2H3R · PDBe 2H3R · UniProt P88989
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