Research workbench
RESA E80Q
Analyse RESA E80Q in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2H1B
- Type
- protein
- Length
- 550 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Thiol-disulfide oxidoreductase resa
- UniProt
- P35160
- Pockets
- 5 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 36% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Thiol-disulfide oxidoreductase resa | protein | 138 | 36% helix, 29% strand | P35160 |
| C, D | Thiol-disulfide oxidoreductase resa | protein | 137 | 36% helix, 28% strand | P35160 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 7 copies · chains A, B, C, D
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 820 | 0.71 | 0.77 | 55 | empty |
| 2 | 189 | 0.45 | 0.74 | 28 | empty |
| 3 | 139 | 0.41 | 0.75 | 26 | empty |
| 4 | 85 | 0.33 | 0.74 | 21 | empty |
| 5 | 65 | 0.32 | 0.75 | 15 | empty |
Interfaces
5 interfaces between chains.
- A–D · 524 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 432 Ų buried · 3 hydrogen bonds · protein-protein
- B–C · 402 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 260 Ų buried · 2 hydrogen bonds · protein-protein
- A–B · 42 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P35160
- Elsewhere: RCSB PDB 2H1B · PDBe 2H1B · UniProt P35160
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