Research workbench

Alcohol dehydrogenase from drosophila lebanonensis

Analyse Alcohol dehydrogenase from drosophila lebanonensis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 1A4U
Type: protein
Length: 508 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Alcohol dehydrogenase
EC: 1.1.1.1
UniProt: P10807
Pockets: 5 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Alcohol dehydrogenase (EC 1.1.1.1)	protein	254	43% helix, 19% strand	P10807

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	539	0.74	0.81	52	empty
2	492	0.74	0.82	48	empty
3	86	0.45	0.81	27	empty
4	54	0.41	0.82	20	empty
5	53	0.30	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 2625 Å² buried · 23 hydrogen bonds · protein-protein

Compared structures

1A4U · Alcohol dehydrogenase from drosophila lebanonensis · the same entry in another collection · chain A against A, TM-score 1.00
P10807 · AlphaFold monomer V2.0 prediction for alcohol dehydrogenase (P10807) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10807
Elsewhere: RCSB PDB 1A4U · PDBe 1A4U · UniProt P10807

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