Research workbench
Crystal structure of SFI1P/CDC31P complex
Analyse Crystal structure of SFI1P/CDC31P complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GV5
- Type
- protein
- Length
- 738 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cell division control protein 31; SFI1P
- UniProt
- P06704, Q12369
- Pockets
- 7 · best druggability 0.58
Structure
x-ray diffraction · 4 distinct chains · 63% helix, 5% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cell division control protein 31 | protein | 149 | 58% helix, 7% strand | P06704 |
| B, E | Cell division control protein 31 | protein | 148 | 60% helix, 5% strand | P06704 |
| C, F | SFI1P | protein | 73 | 88% helix, 0% strand | Q12369 |
| D | Cell division control protein 31 | protein | 147 | 59% helix, 7% strand | P06704 |
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 319 | 0.58 | 0.77 | 31 | empty |
| 2 | 275 | 0.58 | 0.78 | 29 | empty |
| 3 | 242 | 0.56 | 0.78 | 30 | empty |
| 4 | 207 | 0.56 | 0.79 | 25 | empty |
| 5 | 214 | 0.55 | 0.78 | 27 | empty |
Interfaces
7 interfaces between chains.
- B–C · 1648 Ų buried · 16 hydrogen bonds · protein-protein
- E–F · 1635 Ų buried · 15 hydrogen bonds · protein-protein
- D–F · 1427 Ų buried · 8 hydrogen bonds · protein-protein
- A–C · 1424 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 346 Ų buried · 4 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 22 modified (engineered).
Compared structures
- 2GV5 · crystal structure of Sfi1p/Cdc31p complex · the same entry in another collection · chain F against F, TM-score 1.00
- P06704 · AlphaFold monomer V2.0 prediction for cell division control protein 31 (P06704) · a predicted model of the same protein · chain E against A, TM-score 0.87
- Q12369 · AlphaFold monomer V2.0 prediction for protein SFI1 (Q12369) · a predicted model of the same protein · chain C against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06704
- Every structure of UniProt Q12369
- Elsewhere: RCSB PDB 2GV5 · PDBe 2GV5 · UniProt P06704 · UniProt Q12369
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.