Research workbench
Mutation of mhv coronavirus non-structural protein NSP15 (F307L)
Analyse Mutation of mhv coronavirus non-structural protein NSP15 (F307L) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GTI
- Type
- protein
- Length
- 348 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Replicase polyprotein 1AB
- UniProt
- P16342
- Ligands
- SO4
- Pockets
- 4 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 21% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Replicase polyprotein 1AB | protein | 348 | 21% helix, 29% strand | P16342 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 260 | 0.60 | 0.79 | 40 | empty |
| 2 | 179 | 0.50 | 0.77 | 30 | empty |
| 3 | 130 | 0.42 | 0.76 | 19 | empty |
| 4 | 60 | 0.26 | 0.72 | 14 | empty |
Modifications
Observed in the structure: 5 modified (engineered).
Compared structures
- 2GTI · mutation of MHV coronavirus non-structural protein nsp15 (F307L) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P16342
- Elsewhere: RCSB PDB 2GTI · PDBe 2GTI · UniProt P16342
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