Research workbench
Crystal structure of the biotin carboxylase subunit, E23R mutant, of acetyl-CoA carboxylase from escherichia COLI.
Analyse Crystal structure of the biotin carboxylase subunit, E23R mutant, of acetyl-CoA… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GPS
- Type
- protein
- Length
- 893 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Biotin carboxylase
- EC
- 6.3.4.14
- UniProt
- P24182
- Pockets
- 9 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 35% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Biotin carboxylase (EC 6.3.4.14) | protein | 447 | 34% helix, 23% strand | P24182 |
| B | Biotin carboxylase (EC 6.3.4.14) | protein | 446 | 35% helix, 27% strand | P24182 |
Pockets
9 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 585 | 0.75 | 0.82 | 55 | empty |
| 2 | 64 | 0.69 | 0.96 | 21 | empty |
| 3 | 291 | 0.54 | 0.75 | 35 | empty |
| 4 | 200 | 0.49 | 0.76 | 24 | empty |
| 5 | 118 | 0.44 | 0.78 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1338 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 2GPS · Crystal Structure of the Biotin Carboxylase Subunit, E23R mutant, of Acetyl-CoA… · the same entry in another collection · chain A against A, TM-score 1.00
- P24182 · AlphaFold monomer V2.0 prediction for biotin carboxylase (P24182) · a predicted model of the same protein · chain B against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P24182
- Elsewhere: RCSB PDB 2GPS · PDBe 2GPS · UniProt P24182
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