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Structural and functional analysis of natrin, a member of crisp-3 family blocks a variety of ion channels

Analyse Structural and functional analysis of natrin, a member of crisp-3 family blocks… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GIZ
Type: protein
Length: 432 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Natrin-1
UniProt: Q7T1K6
Pockets: 3 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 19% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Natrin-1	protein	216	32% helix, 19% strand	Q7T1K6

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	348	0.66	0.81	36	empty
2	523	0.66	0.77	60	empty
3	51	0.23	0.72	14	empty

Interfaces

1 interface between chains.

A–B · 339 Å² buried · 9 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 16 disulfide (disulfide).

Compared structures

2GIZ · Structural and functional analysis of Natrin, a member of crisp-3 family blocks a variety… · the same entry in another collection · chain A against A, TM-score 1.00
Q7T1K6 · AlphaFold monomer V2.0 prediction for cysteine-rich venom protein natrin-1 (Q7T1K6) · a predicted model of the same protein · chain B against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q7T1K6
Elsewhere: RCSB PDB 2GIZ · PDBe 2GIZ · UniProt Q7T1K6

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