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Cytoplasmic domain structure of KIR2.1 containing ANDERSEN'S mutation R218Q and rescue mutation T309K

Analyse Cytoplasmic domain structure of KIR2.1 containing ANDERSEN'S mutation R218Q and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GIX
Type: protein
Length: 818 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Inward rectifier potassium channel 2
UniProt: P35561
Ligands: K
Pockets: 19 · best druggability 0.85

Structure

x-ray diffraction · 3 distinct chains · 10% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, C	Inward rectifier potassium channel 2	protein	206	13% helix, 45% strand	P35561
B	Inward rectifier potassium channel 2	protein	201	8% helix, 43% strand	P35561
D	Inward rectifier potassium channel 2	protein	205	10% helix, 44% strand	P35561

Ligands and binding sites

K · Potassium ion · metal
MPD · (4S)-2-methyl-2,4-pentanediol · additive · 4 copies · chains A, D, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

19 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	923	0.85	0.87	55	K
2	429	0.73	0.83	49	empty
3	433	0.72	0.82	42	empty
4	450	0.72	0.82	56	empty
5	435	0.72	0.82	43	empty

Interfaces

5 interfaces between chains.

B–C · 1802 Å² buried · 39 hydrogen bonds · protein-protein
A–B · 1768 Å² buried · 39 hydrogen bonds · protein-protein
A–D · 1750 Å² buried · 37 hydrogen bonds · protein-protein
C–D · 1733 Å² buried · 41 hydrogen bonds · protein-protein
B–D · 57 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2GIX · Cytoplasmic Domain Structure of Kir2.1 containing Andersen's Mutation R218Q and Rescue… · the same entry in another collection · chain A against A, TM-score 1.00
P35561 · AlphaFold monomer V2.0 prediction for inward rectifier potassium channel 2 (P35561) · a predicted model of the same protein · chain A against A, TM-score 0.86

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P35561
Elsewhere: RCSB PDB 2GIX · PDBe 2GIX · UniProt P35561

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