Research workbench

Crystal structure of the west nile virus NS2B-NS3 protease, HIS51ALA mutant

Analyse Crystal structure of the west nile virus NS2B-NS3 protease, HIS51ALA mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2GGV
Type: protein
Length: 213 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Non-structural protein 2B; Non-structural protein 3
UniProt: Q203W3
Pockets: 1 · best druggability 0.45

Structure

x-ray diffraction · 2 distinct chains · 6% helix, 44% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Non-structural protein 2B	protein	44	14% helix, 36% strand	Q203W3
B	Non-structural protein 3	protein	169	4% helix, 46% strand	Q203W3

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	169	0.45	0.75	28	empty

Interfaces

1 interface between chains.

A–B · 1457 Å² buried · 28 hydrogen bonds · protein-protein

Compared structures

2GGV · Crystal structure of the West Nile virus NS2B-NS3 protease, His51Ala mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q203W3
Elsewhere: RCSB PDB 2GGV · PDBe 2GGV · UniProt Q203W3

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.