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Crystal structure of human hydroxyisobutyrate dehydrogenase
Analyse Crystal structure of human hydroxyisobutyrate dehydrogenase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GF2
- Type
- protein
- Length
- 1,174 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3-hydroxyisobutyrate dehydrogenase
- EC
- 1.1.1.31
- UniProt
- P31937
- Pockets
- 6 · best druggability 0.68
Structure
x-ray diffraction · 4 distinct chains · 52% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) | protein | 296 | 52% helix, 14% strand | P31937 |
| B | 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) | protein | 293 | 52% helix, 14% strand | P31937 |
| C | 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) | protein | 291 | 53% helix, 14% strand | P31937 |
| D | 3-hydroxyisobutyrate dehydrogenase (EC 1.1.1.31) | protein | 294 | 52% helix, 14% strand | P31937 |
Pockets
6 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 684 | 0.68 | 0.76 | 83 | empty |
| 2 | 440 | 0.65 | 0.78 | 56 | empty |
| 3 | 398 | 0.65 | 0.78 | 47 | empty |
| 4 | 387 | 0.63 | 0.78 | 50 | empty |
| 5 | 256 | 0.52 | 0.75 | 54 | empty |
Interfaces
6 interfaces between chains.
- B–C · 2517 Ų buried · 26 hydrogen bonds · protein-protein
- A–D · 2478 Ų buried · 27 hydrogen bonds · protein-protein
- B–D · 727 Ų buried · 5 hydrogen bonds · protein-protein
- A–C · 699 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 417 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2GF2 · Crystal structure of human hydroxyisobutyrate dehydrogenase · the same entry in another collection · chain D against D, TM-score 1.00
- P31937 · AlphaFold monomer V2.0 prediction for 3-hydroxyisobutyrate dehydrogenase, mitochondrial… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P31937
- Elsewhere: RCSB PDB 2GF2 · PDBe 2GF2 · UniProt P31937
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