Research workbench
Crystal structure of phosphatidylinositol mannosyltransferase (pima) from mycobacterium smegmatis in complex with GDP-man
Analyse Crystal structure of phosphatidylinositol mannosyltransferase (pima) from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GEJ
- Type
- protein
- Length
- 361 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Phosphatidylinositol mannosyltransferase (pima)
- UniProt
- A0QWG6
- Ligands
- GDD
- Pockets
- 3 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Phosphatidylinositol mannosyltransferase (pima) | protein | 361 | 47% helix, 16% strand | A0QWG6 |
Ligands and binding sites
- GDD · Guanosine-5'-diphosphate-alpha-D-mannose · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 640 | 0.76 | 0.81 | 59 | GDD |
| 2 | 89 | 0.48 | 0.82 | 21 | empty |
| 3 | 71 | 0.34 | 0.76 | 14 | empty |
Compared structures
- 2GEJ · Crystal Structure of phosphatidylinositol mannosyltransferase (PimA) from Mycobacterium… · the same entry in another collection · chain A against A, TM-score 1.00
- A0QWG6 · AlphaFold monomer V2.0 prediction for phosphatidyl-myo-inositol mannosyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A0QWG6
- Elsewhere: RCSB PDB 2GEJ · PDBe 2GEJ · UniProt A0QWG6
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