Research workbench
Structure of the POB3 middle domain
Analyse Structure of the POB3 middle domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2GCL
- Type
- protein
- Length
- 461 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hypothetical 63.0 kda protein in DAK1-ORC1 intergenic region
- UniProt
- Q04636
- Ligands
- CL
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 17% helix, 51% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hypothetical 63.0 kda protein in DAK1-ORC1 intergenic region | protein | 230 | 17% helix, 52% strand | Q04636 |
| B | Hypothetical 63.0 kda protein in DAK1-ORC1 intergenic region | protein | 231 | 17% helix, 51% strand | Q04636 |
Ligands and binding sites
- CL · Chloride ion · ion · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 485 | 0.65 | 0.77 | 65 | CL |
| 2 | 99 | 0.41 | 0.77 | 18 | empty |
| 3 | 66 | 0.36 | 0.78 | 15 | empty |
| 4 | 57 | 0.30 | 0.76 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 957 Ų buried · 16 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04636
- Elsewhere: RCSB PDB 2GCL · PDBe 2GCL · UniProt Q04636
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.