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Crystal structure of RV1846C, a putative transcriptional regulatory protein of mycobacterium tuberculosis

Analyse Crystal structure of RV1846C, a putative transcriptional regulatory protein of… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2G9W
Type: protein
Length: 238 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Conserved hypothetical protein
UniProt: P95163
Ligands: CL
Pockets: 2 · best druggability 0.34

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 8% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Conserved hypothetical protein	protein	119	65% helix, 8% strand	P95163

Ligands and binding sites

CL · Chloride ion · ion · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	66	0.34	0.76	20	empty
2	51	0.31	0.77	12	empty

Interfaces

1 interface between chains.

A–B · 2189 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 modified (engineered).

Compared structures

2G9W · Crystal Structure of Rv1846c, a Putative Transcriptional Regulatory Protein of… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P95163
Elsewhere: RCSB PDB 2G9W · PDBe 2G9W · UniProt P95163

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