Research workbench
2.3 a structure of putative catechol degradative operon regulator from rhodococcus sp. RHA1
Analyse 2.3 a structure of putative catechol degradative operon regulator from… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2G7U
- Type
- protein
- Length
- 997 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Transcriptional regulator
- UniProt
- O33539
- Pockets
- 6 · best druggability 0.76
Structure
x-ray diffraction · 3 distinct chains · 46% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Transcriptional regulator | protein | 251 | 46% helix, 21% strand | O33539 |
| B | Transcriptional regulator | protein | 250 | 45% helix, 21% strand | O33539 |
| C, D | Transcriptional regulator | protein | 248 | 47% helix, 20% strand | O33539 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1035 | 0.76 | 0.78 | 99 | empty |
| 2 | 713 | 0.75 | 0.81 | 83 | empty |
| 3 | 390 | 0.58 | 0.75 | 40 | empty |
| 4 | 268 | 0.50 | 0.74 | 33 | empty |
| 5 | 130 | 0.44 | 0.77 | 22 | empty |
Interfaces
5 interfaces between chains.
- A–B · 2733 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 2314 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 894 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 819 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 118 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 2G7U · 2.3 A structure of putative catechol degradative operon regulator from Rhodococcus sp.… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O33539
- Elsewhere: RCSB PDB 2G7U · PDBe 2G7U · UniProt O33539
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.