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Structure of an O6-methylguanine DNA methyltransferase from methanococcus jannaschii (MJ1529)

Analyse Structure of an O6-methylguanine DNA methyltransferase from methanococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2G7H
Type: protein
Length: 167 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Methylated-DNA--protein-cysteine methyltransferase
EC: 2.1.1.63
UniProt: Q58924
Pockets: 3 · best druggability 0.76

Structure

solution nmr · 1 distinct chain · 32% helix, 13% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63)	protein	167	32% helix, 13% strand	Q58924

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	362	0.76	0.86	62	empty
2	110	0.41	0.76	19	empty
3	79	0.34	0.75	17	empty

Compared structures

2G7H · Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii… · the same entry in another collection · chain A against A, TM-score 1.00
Q58924 · AlphaFold monomer V2.0 prediction for methylated-DNA--protein- cysteine methyltransferase… · a predicted model of the same protein · chain A against A, TM-score 0.78

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q58924
Elsewhere: RCSB PDB 2G7H · PDBe 2G7H · UniProt Q58924

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