Research workbench
Crystal structure of human SPERMIDINE/SPERMINE N1-acetyltransferase (hssat)
Analyse Crystal structure of human SPERMIDINE/SPERMINE N1-acetyltransferase (hssat) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2G3T
- Type
- protein
- Length
- 337 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Diamine acetyltransferase 1
- EC
- 2.3.1.57
- UniProt
- P21673
- Pockets
- 5 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Diamine acetyltransferase 1 (EC 2.3.1.57) | protein | 169 | 40% helix, 21% strand | P21673 |
| B | Diamine acetyltransferase 1 (EC 2.3.1.57) | protein | 168 | 40% helix, 21% strand | P21673 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 795 | 0.70 | 0.76 | 64 | empty |
| 2 | 352 | 0.60 | 0.77 | 28 | empty |
| 3 | 168 | 0.50 | 0.77 | 21 | empty |
| 4 | 143 | 0.43 | 0.75 | 19 | empty |
| 5 | 95 | 0.33 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 26 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2G3T · Crystal structure of human spermidine/spermine N1-acetyltransferase (hSSAT) · the same entry in another collection · chain A against A, TM-score 1.00
- P21673 · AlphaFold monomer V2.0 prediction for diamine acetyltransferase 1 (P21673) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P21673
- Elsewhere: RCSB PDB 2G3T · PDBe 2G3T · UniProt P21673
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