Research workbench
Use of an N-terminal fragment from moloney murine leukemia virus reverse transcriptase to facilitate crystallization and analysis of a pseudo-16-mer DNA molecule containing G- a mispairs
Analyse Use of an N-terminal fragment from moloney murine leukemia virus reverse… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 1D1U
- Type
- protein + DNA
- Length
- 271 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- DNA (5'-D(*CP*TP*CP*GP*TP*G)-3'); DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3'); Protein…
- EC
- 2.7.7.7
- UniProt
- P03355
- Pockets
- 1 · best druggability 0.51
Structure
x-ray diffraction · 3 distinct chains · 30% helix, 22% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | DNA (5'-D(*CP*TP*CP*GP*TP*G)-3') | dna | 6 | — | — |
| C | DNA (5'-D(*AP*CP*GP*GP*CP*AP*CP*GP*AP*G)-3') | dna | 10 | — | — |
| A | Protein (reverse transcriptase) (EC 2.7.7.7) | protein | 255 | 30% helix, 22% strand | P03355 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 259 | 0.51 | 0.75 | 37 | empty |
Interfaces
3 interfaces between chains.
- B–C · 299 Ų buried · 25 hydrogen bonds · nucleic-nucleic
- C–A · 213 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–A · 209 Ų buried · 3 hydrogen bonds · protein-nucleic
Compared structures
- 1D1U · Use of an N-terminal fragment from moloney murine leukemia virus reverse transcriptase to… · the same entry in another collection · chain B against B, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03355
- Elsewhere: RCSB PDB 1D1U · PDBe 1D1U · UniProt P03355
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