Research workbench

Nisin cyclase

Analyse Nisin cyclase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2G0D
Type: protein
Length: 404 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nisin biosynthesis protein nisc
UniProt: Q03202
Ligands: ZN
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 61% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nisin biosynthesis protein nisc	protein	404	61% helix, 1% strand	Q03202

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	133	0.50	0.79	20	empty
2	51	0.37	0.79	14	empty
3	85	0.36	0.75	24	empty
4	64	0.34	0.77	15	empty

Compared structures

2G0D · Nisin cyclase · the same entry in another collection · chain A against A, TM-score 1.00
Q03202 · AlphaFold monomer V2.0 prediction for nisin biosynthesis protein nisc (Q03202) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q03202
Elsewhere: RCSB PDB 2G0D · PDBe 2G0D · UniProt Q03202

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