Research workbench
Crystal structure of fatty acid-CoA racemase from mycobacterium tuberculosis H37RV
Analyse Crystal structure of fatty acid-CoA racemase from mycobacterium tuberculosis… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2G04
- Type
- protein
- Length
- 2,118 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable fatty-acid-CoA racemase far
- EC
- 5.1.99.4
- UniProt
- O53867
- Pockets
- 20 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F | Probable fatty-acid-CoA racemase far (EC 5.1.99.4) | protein | 353 | 37% helix, 14% strand | O53867 |
Pockets
20 pockets found on a 1 Å grid, 17 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 613 | 0.73 | 0.80 | 60 | empty |
| 2 | 629 | 0.72 | 0.79 | 66 | empty |
| 3 | 640 | 0.72 | 0.79 | 62 | empty |
| 4 | 582 | 0.71 | 0.79 | 57 | empty |
| 5 | 605 | 0.71 | 0.79 | 60 | empty |
Interfaces
6 interfaces between chains.
- A–B · 6426 Ų buried · 104 hydrogen bonds · protein-protein
- C–D · 6424 Ų buried · 105 hydrogen bonds · protein-protein
- E–F · 6410 Ų buried · 106 hydrogen bonds · protein-protein
- C–F · 79 Ų buried · 0 hydrogen bonds · protein-protein
- B–F · 79 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 2G04 · Crystal structure of fatty acid-CoA racemase from Mycobacterium tuberculosis H37Rv · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O53867
- Elsewhere: RCSB PDB 2G04 · PDBe 2G04 · UniProt O53867
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