Research workbench
The role of T cell receptor alpha genes in directing human MHC restriction
Analyse The role of T cell receptor alpha genes in directing human MHC restriction in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FZ3
- Type
- protein
- Length
- 386 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HLA class I histocompatibility antigen, B-35 alpha chain; Beta-2-microglobulin; 11-mer…
- UniProt
- P30474, P61769, P03211
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 18% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | HLA class I histocompatibility antigen, B-35 alpha chain | protein | 276 | 25% helix, 39% strand | P30474 |
| B | Beta-2-microglobulin | protein | 99 | 0% helix, 52% strand | P61769 |
| C | 11-mer peptide from epstein-barr nuclear antigen 1 | protein | 11 | 0% helix, 0% strand | P03211 |
Pockets
5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 598 | 0.68 | 0.78 | 48 | empty |
| 2 | 196 | 0.53 | 0.78 | 32 | empty |
| 3 | 85 | 0.42 | 0.79 | 17 | empty |
| 4 | 51 | 0.34 | 0.79 | 15 | empty |
| 5 | 50 | 0.25 | 0.73 | 15 | empty |
Interfaces
2 interfaces between chains.
- A–B · 1324 Ų buried · 26 hydrogen bonds · protein-protein
- A–C · 860 Ų buried · 19 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 2FZ3 · The role of T cell receptor alpha genes in directing human MHC restriction · the same entry in another collection · chain A against A, TM-score 1.00
- P61769 · AlphaFold monomer V2.0 prediction for beta-2-microglobulin (P61769) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30474
- Every structure of UniProt P61769
- Every structure of UniProt P03211
- Elsewhere: RCSB PDB 2FZ3 · PDBe 2FZ3 · UniProt P30474 · UniProt P61769 · UniProt P03211
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