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Crystal structure of a conserved protein of unknown function from streptococcus pneumoniae

Analyse Crystal structure of a conserved protein of unknown function from streptococcus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FYW
Type: protein
Length: 800 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Conserved hypothetical protein
Pockets: 6 · best druggability 0.78

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Conserved hypothetical protein	protein	267	38% helix, 25% strand	—
C	Conserved hypothetical protein	protein	266	39% helix, 24% strand	—

Pockets

6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	849	0.78	0.81	101	empty
2	170	0.51	0.78	22	empty
3	133	0.49	0.79	21	empty
4	202	0.48	0.75	34	empty
5	74	0.33	0.75	20	empty

Interfaces

1 interface between chains.

A–B · 1869 Å² buried · 30 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 18 modified (engineered).

Compared structures

2FYW · Crystal Structure of a Conserved Protein of Unknown Function from Streptococcus pneumoniae · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2FYW · PDBe 2FYW

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