Research workbench
Crystal structure of the cofactor-binding domain of the cbl transcriptional regulator
Analyse Crystal structure of the cofactor-binding domain of the cbl transcriptional… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FYI
- Type
- protein
- Length
- 897 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hth-type transcriptional regulator cbl
- UniProt
- Q47083
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 34% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, D | Hth-type transcriptional regulator cbl | protein | 223 | 35% helix, 27% strand | Q47083 |
| C | Hth-type transcriptional regulator cbl | protein | 228 | 33% helix, 26% strand | Q47083 |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 157 | 0.69 | 0.88 | 43 | empty |
| 2 | 179 | 0.49 | 0.77 | 24 | empty |
| 3 | 52 | 0.40 | 0.82 | 16 | empty |
| 4 | 62 | 0.36 | 0.78 | 15 | empty |
| 5 | 67 | 0.36 | 0.77 | 14 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1503 Ų buried · 33 hydrogen bonds · protein-protein
- B–C · 610 Ų buried · 9 hydrogen bonds · protein-protein
- A–D · 571 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 2FYI · Crystal Structure of the Cofactor-Binding Domain of the Cbl Transcriptional Regulator · the same entry in another collection · chain D against D, TM-score 1.00
- Q47083 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator cbl (Q47083) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q47083
- Elsewhere: RCSB PDB 2FYI · PDBe 2FYI · UniProt Q47083
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