Research workbench
Crystal structure of the macro-domain of human core histone variant MACROH2A1.1 (form a)
Analyse Crystal structure of the macro-domain of human core histone variant MACROH2A1.1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FXK
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- H2A histone family, member Y isoform 1
- Pockets
- 4 · best druggability 0.71
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | H2A histone family, member Y isoform 1 | protein | 187 | 42% helix, 20% strand | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 397 | 0.71 | 0.82 | 41 | empty |
| 2 | 147 | 0.59 | 0.83 | 27 | empty |
| 3 | 136 | 0.54 | 0.82 | 26 | empty |
| 4 | 72 | 0.33 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 335 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
- 2FXK · Crystal structure of the macro-domain of human core histone variant macroH2A1.1 (form A) · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 2FXK · PDBe 2FXK
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