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Crystal structure of RV1848, a urease gamma subunit urea (urea amidohydrolase), from mycobacterium tuberculosis

Analyse Crystal structure of RV1848, a urease gamma subunit urea (urea amidohydrolase)… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FVH
Type: protein
Length: 297 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Urease gamma subunit
EC: 3.5.1.5
UniProt: P0A676
Pockets: 2 · best druggability 0.67

Structure

x-ray diffraction · 1 distinct chain · 54% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C	Urease gamma subunit (EC 3.5.1.5)	protein	99	54% helix, 18% strand	P0A676

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	532	0.67	0.78	65	empty
2	400	0.60	0.76	39	empty

Interfaces

3 interfaces between chains.

A–C · 715 Å² buried · 19 hydrogen bonds · protein-protein
A–B · 645 Å² buried · 20 hydrogen bonds · protein-protein
B–C · 596 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

2FVH · Crystal Structure of Rv1848, a Urease Gamma Subunit UreA (Urea amidohydrolase), from… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P0A676
Elsewhere: RCSB PDB 2FVH · PDBe 2FVH · UniProt P0A676

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