Research workbench

Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (apo form)

Analyse Zinc-beta-lactamase L1 from stenotrophomonas maltophilia (apo form) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FU6
Type: protein
Length: 532 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Metallo-beta-lactamase L1
EC: 3.5.2.6
UniProt: P52700
Ligands: SO4
Pockets: 4 · best druggability 0.63

Structure

x-ray diffraction · 1 distinct chain · 30% helix, 24% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Metallo-beta-lactamase L1 (EC 3.5.2.6)	protein	266	30% helix, 24% strand	P52700

Ligands and binding sites

SO4 · Sulfate ion · ion · 8 copies · chains A, B
GOL · Glycerol · additive · 3 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	227	0.63	0.82	37	empty
2	120	0.42	0.76	27	empty
3	104	0.40	0.76	26	empty
4	58	0.28	0.74	11	GOL

Interfaces

1 interface between chains.

A–B · 1328 Å² buried · 12 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2FU6 · Zinc-beta-lactamase l1 from stenotrophomonas maltophilia (apo form) · the same entry in another collection · chain A against A, TM-score 1.00
P52700 · AlphaFold monomer V2.0 prediction for metallo-beta-lactamase L1 type 3 (P52700) · a predicted model of the same protein · chain B against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52700
Elsewhere: RCSB PDB 2FU6 · PDBe 2FU6 · UniProt P52700

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.