Research workbench
Crystal structure of the DNA binding domain of E.COLI fur (ferric uptake regulator)
Analyse Crystal structure of the DNA binding domain of E.COLI fur (ferric uptake… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FU4
- Type
- protein
- Length
- 162 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ferric uptake regulation protein
- UniProt
- P0A9A9
- Ligands
- CD, CL
- Pockets
- 1 · best druggability 0.53
Structure
x-ray diffraction · 1 distinct chain · 58% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ferric uptake regulation protein | protein | 81 | 58% helix, 14% strand | P0A9A9 |
Ligands and binding sites
- CD · Cadmium ion · metal · 8 copies · chains A, B
- CL · Chloride ion · ion · 12 copies · chains A, B
- GOL · Glycerol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 100 | 0.53 | 0.83 | 22 | CD |
Interfaces
1 interface between chains.
- A–B · 552 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 2FU4 · Crystal Structure of the DNA binding domain of E.coli FUR (Ferric Uptake Regulator) · the same entry in another collection · chain A against A, TM-score 1.00
- P0A9A9 · AlphaFold monomer V2.0 prediction for ferric uptake regulation protein (P0A9A9) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0A9A9
- Elsewhere: RCSB PDB 2FU4 · PDBe 2FU4 · UniProt P0A9A9
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