Research workbench
Structural model for the large subunit of the mammalian mitochondrial ribosome
Analyse Structural model for the large subunit of the mammalian mitochondrial ribosome in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FTC
- Type
- protein
- Length
- 2,093 residues
- Chains
- 17
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitochondrial ribosomal protein L1; Mitochondrial ribosomal protein L2; Mitochondrial 39S…
- UniProt
- Q7YR75
- Pockets
- 1 · best druggability 0.38
Structure
electron microscopy · 16 distinct chains · 0% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitochondrial ribosomal protein L1 | protein | 189 | 0% helix, 0% strand | — |
| B | Mitochondrial ribosomal protein L2 | protein | 136 | 0% helix, 0% strand | — |
| C | Mitochondrial 39S ribosomal protein L3 | protein | 211 | 0% helix, 0% strand | — |
| D | Mitochondrial ribosomal protein L4 isoform a | protein | 175 | 0% helix, 0% strand | — |
| E, F | 39S ribosomal protein L12, mitochondrial | protein | 137 | 0% helix, 0% strand | Q7YR75 |
| G | 39S ribosomal protein L11, mitochondrial | protein | 145 | 0% helix, 0% strand | — |
| H | 39S ribosomal protein L13, mitochondrial | protein | 148 | 0% helix, 0% strand | — |
| I | Mitochondrial ribosomal protein L16 | protein | 118 | 0% helix, 0% strand | — |
| J | Mitochondrial ribosomal protein L17 | protein | 116 | 0% helix, 0% strand | — |
| K | 39S ribosomal protein L19, mitochondrial | protein | 98 | 0% helix, 0% strand | — |
| L | MRPL20 protein | protein | 118 | 0% helix, 0% strand | — |
| M | Mitochondrial ribosomal protein L22 isoform a | protein | 110 | 0% helix, 0% strand | — |
| N | Mitochondrial ribosomal protein L24 | protein | 96 | 0% helix, 0% strand | — |
| O | Mitochondrial 39S ribosomal protein L27 | protein | 69 | 0% helix, 0% strand | — |
| P | Mitochondrial ribosomal protein L33 isoform a | protein | 52 | 0% helix, 0% strand | — |
| Q | 39S ribosomal protein L34, mitochondrial | protein | 38 | 0% helix, 0% strand | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 103 | 0.38 | 0.73 | 26 | empty |
Interfaces
3 interfaces between chains.
- E–F · 112 Ų buried · 0 hydrogen bonds · protein-protein
- C–K · 32 Ų buried · 0 hydrogen bonds · protein-protein
- H–L · 26 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 2FTC · Structural Model for the Large Subunit of the Mammalian Mitochondrial Ribosome · the same entry in another collection · chain Q against Q, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7YR75
- Elsewhere: RCSB PDB 2FTC · PDBe 2FTC · UniProt Q7YR75
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