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Crystal structure of the IB1 SH3 dimer at low resolution

Analyse Crystal structure of the IB1 SH3 dimer at low resolution in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FPF
Type: protein
Length: 240 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: C-jun-amino-terminal kinase interacting protein 1
UniProt: Q9R237
Pockets: 1 · best druggability 0.74

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 47% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	C-jun-amino-terminal kinase interacting protein 1	protein	60	5% helix, 47% strand	Q9R237

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	309	0.74	0.86	70	empty

Interfaces

6 interfaces between chains.

A–D · 872 Å² buried · 14 hydrogen bonds · protein-protein
B–C · 866 Å² buried · 13 hydrogen bonds · protein-protein
A–B · 364 Å² buried · 4 hydrogen bonds · protein-protein
C–D · 335 Å² buried · 5 hydrogen bonds · protein-protein
A–C · 105 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

2FPF · Crystal structure of the ib1 sh3 dimer at low resolution · the same entry in another collection · chain A against A, TM-score 1.00
Q9R237 · AlphaFold monomer V2.0 prediction for C-jun-amino-terminal kinase- interacting protein 1… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9R237
Elsewhere: RCSB PDB 2FPF · PDBe 2FPF · UniProt Q9R237

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