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Psec aminotransferase involved in pseudoaminic acid biosynthesis

Analyse Psec aminotransferase involved in pseudoaminic acid biosynthesis in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FNI
Type: protein
Length: 748 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Aminotransferase
Ligands: PLP
Pockets: 7 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 42% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Aminotransferase	protein	374	42% helix, 18% strand	—

Ligands and binding sites

PLP · Pyridoxal-5'-phosphate · ligand · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

7 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	633	0.76	0.82	59	PLP
2	632	0.76	0.82	59	PLP
3	68	0.35	0.77	10	empty
4	61	0.33	0.76	10	empty
5	80	0.31	0.73	14	empty

Interfaces

1 interface between chains.

A–B · 2871 Å² buried · 43 hydrogen bonds · protein-protein

Compared structures

2FNI · PseC aminotransferase involved in pseudoaminic acid biosynthesis · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2FNI · PDBe 2FNI

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