Research workbench
Crystal structure of putative tagatose 6-phosphate kinase
Analyse Crystal structure of putative tagatose 6-phosphate kinase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FIQ
- Type
- protein
- Length
- 1,637 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative tagatose 6-phosphate kinase 1
- EC
- 2.7.1.101
- UniProt
- P37191
- Pockets
- 20 · best druggability 0.75
Structure
x-ray diffraction · 4 distinct chains · 53% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative tagatose 6-phosphate kinase 1 (EC 2.7.1.101) | protein | 410 | 54% helix, 13% strand | P37191 |
| B | Putative tagatose 6-phosphate kinase 1 (EC 2.7.1.101) | protein | 408 | 53% helix, 13% strand | P37191 |
| C | Putative tagatose 6-phosphate kinase 1 (EC 2.7.1.101) | protein | 410 | 53% helix, 12% strand | P37191 |
| D | Putative tagatose 6-phosphate kinase 1 (EC 2.7.1.101) | protein | 409 | 54% helix, 13% strand | P37191 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 889 | 0.75 | 0.79 | 81 | empty |
| 2 | 952 | 0.75 | 0.78 | 90 | empty |
| 3 | 270 | 0.75 | 0.88 | 27 | empty |
| 4 | 233 | 0.75 | 0.89 | 28 | empty |
| 5 | 658 | 0.72 | 0.79 | 67 | empty |
Interfaces
6 interfaces between chains.
- A–B · 1468 Ų buried · 26 hydrogen bonds · protein-protein
- C–D · 1438 Ų buried · 28 hydrogen bonds · protein-protein
- B–C · 348 Ų buried · 4 hydrogen bonds · protein-protein
- A–D · 343 Ų buried · 6 hydrogen bonds · protein-protein
- A–C · 259 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 40 modified (engineered).
Compared structures
- 2FIQ · Crystal structure of putative tagatose 6-phosphate kinase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P37191
- Elsewhere: RCSB PDB 2FIQ · PDBe 2FIQ · UniProt P37191
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