Research workbench
Molecular basis of inhibition of the ribonuclease activity in colicin E5 by its cognate immunity protein
Analyse Molecular basis of inhibition of the ribonuclease activity in colicin E5 by its… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FHZ
- Type
- protein
- Length
- 199 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Colicin-E5 immunity protein; Colicin-E5
- EC
- 3.1.-.-
- UniProt
- P13476, P18000
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 2 distinct chains · 32% helix, 28% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Colicin-E5 immunity protein | protein | 106 | 41% helix, 21% strand | P13476 |
| B | Colicin-E5 (EC 3.1.-.-) | protein | 93 | 23% helix, 37% strand | P18000 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 55 | 0.34 | 0.78 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 1297 Ų buried · 26 hydrogen bonds · protein-protein
Compared structures
- 2FHZ · Molecular Basis of Inhibition of the Ribonuclease Activity in Colicin E5 by Its Cognate… · the same entry in another collection · chain A against A, TM-score 1.00
- P18000 · AlphaFold monomer V2.0 prediction for colicin-E5 (P18000) · a predicted model of the same protein · chain B against A, TM-score 0.96
- P13476 · AlphaFold monomer V2.0 prediction for colicin-E5 immunity protein (P13476) · a predicted model of the same protein · chain A against A, TM-score 0.76
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P13476
- Every structure of UniProt P18000
- Elsewhere: RCSB PDB 2FHZ · PDBe 2FHZ · UniProt P13476 · UniProt P18000
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