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Beta carbonic anhydrase from the carboxysomal shell of halothiobacillus neapolitanus (csosca)

Analyse Beta carbonic anhydrase from the carboxysomal shell of halothiobacillus… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FGY
Type: protein
Length: 942 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Carboxysome shell polypeptide
EC: 4.2.1.1
Ligands: ZN
Pockets: 8 · best druggability 0.85

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 16% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Carboxysome shell polypeptide (EC 4.2.1.1)	protein	471	49% helix, 16% strand	—

Ligands and binding sites

ZN · Zinc ion · metal · 4 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	959	0.85	0.86	101	empty
2	256	0.54	0.76	27	empty
3	250	0.53	0.76	23	empty
4	161	0.51	0.79	17	empty
5	56	0.41	0.82	14	empty

Interfaces

1 interface between chains.

A–B · 1570 Å² buried · 13 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

2FGY · Beta Carbonic Anhydrase from the Carboxysomal Shell of Halothiobacillus neapolitanus… · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 2FGY · PDBe 2FGY

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