Research workbench

Structure of human ferritin L chain

Analyse Structure of human ferritin L chain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FG8
Type: protein
Length: 1,392 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ferritin light chain
UniProt: P02792
Ligands: CS
Pockets: 18 · best druggability 0.73

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Ferritin light chain	protein	174	73% helix, 1% strand	P02792

Ligands and binding sites

CS · Cesium ion · metal · 10 copies · chains A, C, D, E, H, F, G

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

18 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	141	0.73	0.92	28	empty
2	143	0.72	0.91	29	empty
3	147	0.70	0.90	31	empty
4	240	0.59	0.80	34	CS
5	207	0.55	0.79	36	empty

Interfaces

14 interfaces between chains.

E–F · 1595 Å² buried · 33 hydrogen bonds · protein-protein
B–H · 1582 Å² buried · 24 hydrogen bonds · protein-protein
A–D · 1581 Å² buried · 29 hydrogen bonds · protein-protein
E–H · 694 Å² buried · 7 hydrogen bonds · protein-protein
A–C · 684 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

2FG8 · Structure of Human Ferritin L Chain · the same entry in another collection · chain H against H, TM-score 1.00
P02792 · AlphaFold monomer V2.0 prediction for ferritin light chain (P02792) · a predicted model of the same protein · chain E against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P02792
Elsewhere: RCSB PDB 2FG8 · PDBe 2FG8 · UniProt P02792

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.