Research workbench

P450CAM from pseudomonas putida reconstituted with manganic protoporphyrin IX

Analyse P450CAM from pseudomonas putida reconstituted with manganic protoporphyrin IX in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2FE6
Type: protein
Length: 405 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cytochrome P450-cam
EC: 1.14.15.1
UniProt: P00183
Ligands: MNR, K
Pockets: 2 · best druggability 0.87

Structure

x-ray diffraction · 1 distinct chain · 52% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cytochrome P450-cam (EC 1.14.15.1)	protein	405	52% helix, 11% strand	P00183

Ligands and binding sites

MNR · Protoporphyrin IX containing Mn · ligand · chains A
K · Potassium ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	545	0.87	0.92	51	MNR
2	57	0.32	0.77	15	empty

Compared structures

2FE6 · P450CAM from Pseudomonas putida reconstituted with manganic protoporphyrin IX · the same entry in another collection · chain A against A, TM-score 1.00
P00183 · AlphaFold monomer V2.0 prediction for camphor 5-monooxygenase (P00183) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00183
Elsewhere: RCSB PDB 2FE6 · PDBe 2FE6 · UniProt P00183

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