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Dir primaerstruktur des kristallisierbaren monoklonalen immunoglobulins IGG1 kol. II. aminosaeuresequenz der L- kette, lambda-typ, subgruppe I (german)
Analyse Dir primaerstruktur des kristallisierbaren monoklonalen immunoglobulins IGG1… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2FB4
- Type
- protein
- Length
- 445 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IGG1-lambda kol Fab (light chain); IGG1-lambda kol Fab (heavy chain)
- UniProt
- P01772
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 2 distinct chains · 7% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IGG1-lambda kol Fab (light chain) | protein | 216 | 6% helix, 50% strand | — |
| H | IGG1-lambda kol Fab (heavy chain) | protein | 229 | 8% helix, 50% strand | P01772 |
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 296 | 0.63 | 0.80 | 36 | empty |
| 2 | 156 | 0.50 | 0.78 | 28 | empty |
| 3 | 79 | 0.33 | 0.75 | 14 | empty |
| 4 | 92 | 0.32 | 0.73 | 22 | empty |
Interfaces
1 interface between chains.
- L–H · 1921 Ų buried · 17 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 2FB4 · Dir primaerstruktur des kristallisierbaren monoklonalen immunoglobulins IGG1 kol. II.… · the same entry in another collection · chain L against L, TM-score 1.00
- P01772 · AlphaFold monomer V2.0 prediction for immunoglobulin heavy variable 3-33 (P01772) · a predicted model of the same protein · chain H against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01772
- Elsewhere: RCSB PDB 2FB4 · PDBe 2FB4 · UniProt P01772
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