Research workbench

Structure of the type III coaa from pseudomonas aeruginosa

Analyse Structure of the type III coaa from pseudomonas aeruginosa in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2F9T
Type: protein
Length: 489 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Pantothenate kinase
EC: 2.7.1.33
UniProt: Q9HWC1
Pockets: 3 · best druggability 0.75

Structure

x-ray diffraction · 2 distinct chains · 39% helix, 27% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Pantothenate kinase (EC 2.7.1.33)	protein	241	39% helix, 27% strand	Q9HWC1
B	Pantothenate kinase (EC 2.7.1.33)	protein	248	38% helix, 27% strand	Q9HWC1

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	328	0.75	0.87	45	empty
2	438	0.66	0.79	46	empty
3	109	0.35	0.74	18	empty

Interfaces

1 interface between chains.

A–B · 2014 Å² buried · 21 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

2F9T · Structure of the type III CoaA from Pseudomonas aeruginosa · the same entry in another collection · chain A against A, TM-score 1.00
Q9HWC1 · AlphaFold monomer V2.0 prediction for type III pantothenate kinase (Q9HWC1) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9HWC1
Elsewhere: RCSB PDB 2F9T · PDBe 2F9T · UniProt Q9HWC1

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.