Research workbench

Catm effector binding domain with its effector CIS,CIS-muconate

Analyse Catm effector binding domain with its effector CIS,CIS-muconate in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2F7C
Type: protein
Length: 216 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hth-type transcriptional regulator catm
UniProt: P07774
Ligands: CCU, SO4
Pockets: 2 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 32% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Hth-type transcriptional regulator catm	protein	216	32% helix, 29% strand	P07774

Ligands and binding sites

CCU · (2Z,4Z)-hexa-2,4-dienedioic acid · ligand · chains A
SO4 · Sulfate ion · ion · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	121	0.62	0.87	25	CCU
2	75	0.53	0.85	18	empty

Compared structures

2F7C · CatM effector binding domain with its effector cis,cis-muconate · the same entry in another collection · chain A against A, TM-score 1.00
P07774 · AlphaFold monomer V2.0 prediction for hth-type transcriptional regulator catm (P07774) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07774
Elsewhere: RCSB PDB 2F7C · PDBe 2F7C · UniProt P07774

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