Research workbench
Crystallographic structure of human TSG101 uev domain
Analyse Crystallographic structure of human TSG101 uev domain in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2F0R
- Type
- protein
- Length
- 286 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tumor susceptibility gene 101 protein
- UniProt
- Q99816
- Ligands
- SO4
- Pockets
- 5 · best druggability 0.60
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Tumor susceptibility gene 101 protein | protein | 143 | 27% helix, 32% strand | Q99816 |
Ligands and binding sites
- SO4 · Sulfate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 202 | 0.60 | 0.81 | 33 | empty |
| 2 | 98 | 0.44 | 0.79 | 22 | empty |
| 3 | 74 | 0.38 | 0.78 | 19 | empty |
| 4 | 74 | 0.38 | 0.77 | 14 | empty |
| 5 | 57 | 0.31 | 0.75 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 714 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 2F0R · Crystallographic structure of human Tsg101 UEV domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q99816 · AlphaFold monomer V2.0 prediction for tumor susceptibility gene 101 protein (Q99816) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99816
- Elsewhere: RCSB PDB 2F0R · PDBe 2F0R · UniProt Q99816
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