Research workbench

CT10-regulated kinase isoform I

Analyse CT10-regulated kinase isoform I in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 2EYY
Type: protein
Length: 204 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: V-crk sarcoma virus CT10 oncogene homolog isoform a
UniProt: P46108
Pockets: 3 · best druggability 0.46

Structure

solution nmr · 1 distinct chain · 9% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	V-crk sarcoma virus CT10 oncogene homolog isoform a	protein	204	9% helix, 21% strand	P46108

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	134	0.46	0.77	25	empty
2	82	0.44	0.80	17	empty
3	55	0.26	0.73	16	empty

Compared structures

2EYY · CT10-Regulated Kinase isoform I · the same entry in another collection · chain A against A, TM-score 1.00
P46108 · AlphaFold monomer V2.0 prediction for adapter molecule crk (P46108) · a predicted model of the same protein · chain A against A, TM-score 0.47

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46108
Elsewhere: RCSB PDB 2EYY · PDBe 2EYY · UniProt P46108

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