Research workbench
Crystal structure of a probable acetyltransferase
Analyse Crystal structure of a probable acetyltransferase in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 2EUI
- Type
- protein
- Length
- 603 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable acetyltransferase
- UniProt
- Q9HX01
- Pockets
- 10 · best druggability 0.77
Structure
x-ray diffraction · 3 distinct chains · 38% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Probable acetyltransferase | protein | 153 | 37% helix, 31% strand | Q9HX01 |
| B | Probable acetyltransferase | protein | 146 | 38% helix, 34% strand | Q9HX01 |
| E | Probable acetyltransferase | protein | 151 | 38% helix, 32% strand | Q9HX01 |
Pockets
10 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 412 | 0.77 | 0.87 | 55 | empty |
| 2 | 810 | 0.76 | 0.80 | 80 | empty |
| 3 | 233 | 0.73 | 0.88 | 39 | empty |
| 4 | 108 | 0.49 | 0.80 | 18 | empty |
| 5 | 99 | 0.40 | 0.77 | 22 | empty |
Interfaces
3 interfaces between chains.
- D–E · 2909 Ų buried · 61 hydrogen bonds · protein-protein
- A–B · 2829 Ų buried · 59 hydrogen bonds · protein-protein
- B–D · 247 Ų buried · 2 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 16 modified (engineered).
Compared structures
- 2EUI · Crystal structure of a probable acetyltransferase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HX01
- Elsewhere: RCSB PDB 2EUI · PDBe 2EUI · UniProt Q9HX01
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